A delta opioid receptor lacking the third cytoplasmic loop is generated by atypical mRNA processing in human malignomas.

@article{Mayer2000ADO,
  title={A delta opioid receptor lacking the third cytoplasmic loop is generated by atypical mRNA processing in human malignomas.},
  author={Peter Karl Mayer and Helga Tischmeyer and Manori Jayasinghe and Bernd Bonnekoh and Harald P. M. Gollnick and Hj. Teschemacher and Volker Hoellt},
  journal={FEBS letters},
  year={2000},
  volume={480 2-3},
  pages={156-60}
}
delta Opioid receptors were identified in human melanomas by RT-PCR and radioligand binding. In all tumors an additional PCR amplificate was detected in which 144 bp within the third exon were deleted. This fragment corresponded to the third cytoplasmic domain of the receptor protein. The short variant resulted from atypical mRNA processing. There were no common splice recognition sequences around the deleted fragment; instead its excision resembled the removal of a transposon. The deletion was… CONTINUE READING

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