A delicate balance: Iron metabolism and diseases of the brain

@inproceedings{Hare2013ADB,
  title={A delicate balance: Iron metabolism and diseases of the brain},
  author={Dominic Hare and Scott Ayton and Ashley I. Bush and Peng Lei},
  booktitle={Front. Aging Neurosci.},
  year={2013}
}
Iron is the most abundant transition metal within the brain, and is vital for a number of cellular processes including neurotransmitter synthesis, myelination of neurons, and mitochondrial function. Redox cycling between ferrous and ferric iron is utilized in biology for various electron transfer reactions essential to life, yet this same chemistry mediates deleterious reactions with oxygen that induce oxidative stress. Consequently, there is a precise and tightly controlled mechanism to… CONTINUE READING