A deletion in the bovine myostatin gene causes the double–muscled phenotype in cattle

@article{Grobet1997ADI,
  title={A deletion in the bovine myostatin gene causes the double–muscled phenotype in cattle},
  author={L. Grobet and Luis Jos{\'e} Royo Martin and D. Poncelet and D. Pirottin and B. Brouwers and J. Riquet and A. Schoeberlein and S. Dunner and F. M{\'e}nissier and J. Masabanda and R. Fries and R. Hanset and M. Georges},
  journal={Nature Genetics},
  year={1997},
  volume={17},
  pages={71-74}
}
An exceptional muscle development commonly referred to as ‘double-muscled’ (Fig. 1) has been seen in several cattle breeds and has attracted considerable attention from beef producers. Double-muscled animals are characterized by an increase in muscle mass of about 20%, due to general skeletal-muscle hyperplasia—that is, an increase in the number of muscle fibers rather than in their individual diameter1. Although the hereditary nature of the double-muscled condition was recognized early on, the… Expand
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