A deletion at the mouse Xist gene exposes trans-effects that alter the heterochromatin of the inactive X chromosome and the replication time and DNA stability of both X chromosomes.

@article{DiazPerez2006ADA,
  title={A deletion at the mouse Xist gene exposes trans-effects that alter the heterochromatin of the inactive X chromosome and the replication time and DNA stability of both X chromosomes.},
  author={Silvia V. Diaz-Perez and David O. Ferguson and Chen Wang and Gyorgyi Csankovszki and Chengming Wang and S Tsai and Devkanya Dutta and Vanessa N P Perez and Sun Min Kim and C Daniel Eller and Jennifer L. Salstrom and Yan Ouyang and Michael A Teitell and Bernhard Kaltenboeck and Andrew Chess and Sui Huang and York Marahrens},
  journal={Genetics},
  year={2006},
  volume={174 3},
  pages={1115-33}
}
The inactive X chromosome of female mammals displays several properties of heterochromatin including late replication, histone H4 hypoacetylation, histone H3 hypomethylation at lysine-4, and methylated CpG islands. We show that cre-Lox-mediated excision of 21 kb from both Xist alleles in female mouse fibroblasts led to the appearance of two histone modifications throughout the inactive X chromosome usually associated with euchromatin: histone H4 acetylation and histone H3 lysine-4 methylation… CONTINUE READING
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