A delayed antioxidant response in heat-stressed cells expressing a non-DNA binding HSF1 mutant

@article{Hensen2012ADA,
  title={A delayed antioxidant response in heat-stressed cells expressing a non-DNA binding HSF1 mutant},
  author={Sanne M. M. Hensen and Lonneke Heldens and Siebe T. van Genesen and Ger J. M. Pruijn and N. H. Lubsen},
  journal={Cell Stress and Chaperones},
  year={2012},
  volume={18},
  pages={455-473}
}
To assess the consequences of inactivation of heat shock factor 1 (HSF1) during aging, we analyzed the effect of HSF1 K80Q, a mutant unable to bind DNA, and of dnHSF1, a mutant lacking the activation domain, on the transcriptome of cells 6 and 24 h after heat shock. The primary response to heat shock (6 h recovery), of which 30 % was HSF1-dependent, had decayed 24 h after heat shock in control cells but was extended in HSF1 K80Q and dnHSF1 cells. Comparison with literature data showed that even… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 58 references

Signal integration in the endoplasmic reticulum unfolded protein response

Nature Reviews Molecular Cell Biology • 2007
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