A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery.

@article{Forrest2003ADP,
  title={A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery.},
  author={M Laird Forrest and James T Koerber and Daniel W Pack},
  journal={Bioconjugate chemistry},
  year={2003},
  volume={14 5},
  pages={934-40}
}
Routine clinical implementation of human gene therapy awaits safe and efficient gene delivery methods. Polymeric vectors hold promise due to the availability of diverse chemistries, potentially providing targeting, low immunogenicity, nontoxicity, and robustness, but lack sufficient gene delivery efficiency. We have synthesized a versatile group of degradable polycations, through addition of 800-Da polyethylenimine (PEI) to small diacrylate cross-linkers. The degradable polymers reported here… CONTINUE READING

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