A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus.

@article{Willcocks2010ADP,
  title={A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus.},
  author={Lisa C. Willcocks and Edward J. Carr and Heather A. Niederer and Tim F. Rayner and Thomas N Williams and Wanling Yang and J Anthony G Scott and Britta Christina Urban and Norbert Peshu and Timothy J Vyse and Yu Lung Lau and Paul A. Lyons and Kenneth G C Smith},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 17},
  pages={7881-5}
}
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease more prevalent in people of African and Asian origin than Caucasian origin. FcgammaRIIb is an inhibitory Fc receptor with a critical role in immune regulation. Mouse data suggest that FcgammaRIIb deficiency increases susceptibility to autoimmune disease but protects against infection. We show that a SNP in human FCGR2B that abrogates receptor function is strongly associated with susceptibility to SLE in both Caucasians and… CONTINUE READING