A defined subset of adenylyl cyclases is regulated by bicarbonate ion.

  title={A defined subset of adenylyl cyclases is regulated by bicarbonate ion.},
  author={Martin J. Cann and Arne Hammer and Jie Zhou and Tobias Kanacher},
  journal={The Journal of biological chemistry},
  volume={278 37},
The molecular basis by which organisms detect and respond to fluctuations in inorganic carbon is not known. The cyaB1 gene of the cyanobacterium Anabaena sp. PCC7120 codes for a multidomain protein with a C-terminal class III adenylyl cyclase catalyst that was specifically stimulated by bicarbonate ion (EC50 9.6 mm). Bicarbonate lowered substrate affinity but increased reaction velocity. A point mutation in the active site (Lys-646) reduced activity by 95% and was refractory to bicarbonate… CONTINUE READING


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