A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity.

@article{Sebastian2007ADO,
  title={A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity.},
  author={Shite Sebastian and Simon T. Dillon and Jillian G Lynch and Leeann T Blalock and Emmy L Balon and Kristin T Lee and Laurie E. Comstock and J. Wayne Conlan and Eric J. Rubin and Arthur O. Tzianabos and Dennis L Kasper},
  journal={Infection and immunity},
  year={2007},
  volume={75 5},
  pages={2591-602}
}
Francisella tularensis, the causative agent of tularemia, has been designated a CDC category A select agent because of its low infective dose (<10 CFU), its ready transmission by aerosol, and its ability to produce severe morbidity and high mortality. The identification and characterization of this organism's virulence determinants will facilitate the development of a safe and effective vaccine. We report that inactivation of the wbtA-encoded dehydratase of the O-antigen polysaccharide (O-PS… CONTINUE READING

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