A deficit of brain dystrophin impairs specific amygdala GABAergic transmission and enhances defensive behaviour in mice.

@article{Sekiguchi2009ADO,
  title={A deficit of brain dystrophin impairs specific amygdala GABAergic transmission and enhances defensive behaviour in mice.},
  author={Masayuki Sekiguchi and Ko Zushida and Mikiharu Yoshida and Motoko Maekawa and Sari Kamichi and Mizuko Yoshida and Yoshinori Sahara and Shigeki Yuasa and Shin'ichi Takeda and Keiji Wada},
  journal={Brain : a journal of neurology},
  year={2009},
  volume={132 Pt 1},
  pages={124-35}
}
Duchenne muscular dystrophy (DMD) is accompanied by cognitive deficits and psychiatric symptoms. In the brain, dystrophin, the protein responsible for DMD, is localized to a subset of GABAergic synapses, but its role in brain function has not fully been addressed. Here, we report that defensive behaviour, a response to danger or a threat, is enhanced in dystrophin-deficient mdx mice. Mdx mice consistently showed potent defensive freezing responses to a brief restraint that never induced such… CONTINUE READING

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