A deficiency of manganese ions in the presence of high sugar concentrations is the critical parameter for achieving high yields of itaconic acid by Aspergillus terreus

@article{Karaffa2015ADO,
  title={A deficiency of manganese ions in the presence of high sugar concentrations is the critical parameter for achieving high yields of itaconic acid by Aspergillus terreus},
  author={Levente Karaffa and Rafael Garcia Diaz and Benedek Papp and Erzs{\'e}bet Fekete and Erzs{\'e}bet S{\'a}ndor and Christian Peter Kubicek},
  journal={Applied Microbiology and Biotechnology},
  year={2015},
  volume={99},
  pages={7937-7944}
}
Itaconic acid (IA), an unsaturated dicarboxylic acid with a high potential as a platform for chemicals derived from sugars, is industrially produced by large-scale submerged fermentation by Aspergillus terreus. Although the biochemical pathway and the physiology leading to IA is almost the same as that leading to citric acid production in Aspergillus niger, published data for the volumetric (g L−1) and the specific yield (mol/mol carbon source) of IA are significantly lower than for citric acid… CONTINUE READING
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