A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive BALB/c mouse.

@article{Okayasu2000ADI,
  title={A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive BALB/c mouse.},
  author={Ryuichi Okayasu and Katsutoshi Suetomi and Yi Yu and Andrew Silver and Joel S. Bedford and R. B. Cox and Robert L. Ullrich},
  journal={Cancer research},
  year={2000},
  volume={60 16},
  pages={4342-5}
}
We have studied the efficiency of DNA double strand break (DSB) rejoining in primary cells from mouse strains that show large differences in in vivo radiosensitivity and tumor susceptibility. Cells from radiosensitive, cancer-prone BALB/c mice showed inefficient end joining of gamma ray-induced DSBs as compared with cells from all of the other commonly used strains and F1 hybrids of C57BL/6 and BALB/c mice. The BALB/c repair phenotype was accompanied by a significantly reduced expression level… CONTINUE READING
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