A defect of regulatory T cells in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.

@article{Keklinen2007ADO,
  title={A defect of regulatory T cells in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.},
  author={E Kek{\"a}l{\"a}inen and Heli Tuovinen and Joonas Joensuu and Mikhail Gylling and Rauli Franssila and Nora P{\"o}ntynen and Kimmo Talvensaari and Jaakko Perheentupa and Aaro Miettinen and T. Petteri Arstila},
  journal={Journal of immunology},
  year={2007},
  volume={178 2},
  pages={1208-15}
}
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), a monogenic recessive disease characterized by autoimmunity against multiple tissues, offers a unique possibility to study the breakdown of self-tolerance in humans. It is caused by mutations in the autoimmune regulator gene (AIRE), which encodes a transcriptional regulator. Work using Aire(-/-) mice suggests that Aire induces ectopic expression of peripheral Ags and promotes their presentation in the thymus. We have… CONTINUE READING