A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.

@article{Nakase2006ADI,
  title={A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.},
  author={Yukiko Nakase and Keiko Fukuda and Yuji Chikashige and Chihiro Tsutsumi and Daisuke Morita and Shinpei Kawamoto and Mari Ohnuki and Yasushi Hiraoka and Tomohiro Matsumoto},
  journal={Genetics},
  year={2006},
  volume={173 2},
  pages={569-78}
}
Mutations in the human Tsc1 and Tsc2 genes predispose to tuberous sclerosis complex (TSC), a disorder characterized by the wide spread of benign tumors. Tsc1 and Tsc2 proteins form a complex and serve as a GTPase-activating protein (GAP) for Rheb, a GTPase regulating a downstream kinase, mTOR. The genome of Schizosaccharomyces pombe contains tsc1(+) and tsc2(+), homologs of human Tsc1 and Tsc2, respectively. In this study we analyzed the gene expression profile on a genomewide scale and found… CONTINUE READING

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The role of fnx 1 , a fission yeast multidrug resistance protein , in the transition of cells to a quiescent G 0 state

J. R. B roach
Mol . Cell . Biol . • 1998

Tuberous sclerosis

M. P. S hort
Arch . Dermatol . • 1994

Identification and characterization of the tuberous sclerosis gene on chromosome 16

A. S t. J ean
Cell • 1993

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