Corpus ID: 29636770

A defect in histidine biosynthesis causing an adenine deficiency.

@article{Shedlovsky1962ADI,
  title={A defect in histidine biosynthesis causing an adenine deficiency.},
  author={Alexandra Shedlovsky and Boris Magasanik},
  journal={The Journal of biological chemistry},
  year={1962},
  volume={237},
  pages={
          3725-30
        }
}
In recent years, the role of purine nucleotides in the biosynthesis of histidine has been elucidated (2-5). The early steps of histidine biosynthesis comprise the purine nucleotide cycle shown schematically in Fig. 1. Adenosine triphosphate and 5-phosphoribosylpyrophosphate condense to form N-1-phosphoribosyl adenosine triphosphate; this compound is converted in several steps to Compound III in which the bond between N-l and C-2 of the purine ring has been cleaved; Compound III subsequently… Expand
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References

MCELROY AND B. GLASS (Editors), Amino acid metabolism
  • 1955