A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish.

@article{Liu2002ADI,
  title={A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish.},
  author={Shanming Liu and Weining Lu and Tomoko Obara and Shiei Kuida and Jennifer Lehoczky and Ken Dewar and Iain A Drummond and David R Beier},
  journal={Development},
  year={2002},
  volume={129 24},
  pages={
          5839-46
        }
}
The murine autosomal recessive juvenile cystic kidney (jck) mutation results in polycystic kidney disease. We have identified in jck mice a mutation in Nek8, a novel and highly conserved member of the Nek kinase family. In vitro expression of mutated Nek8 results in enlarged, multinucleated cells with an abnormal actin cytoskeleton. To confirm that a defect in the Nek8 gene can cause cystic disease, we performed a cross-species analysis: injection of zebrafish embryos with a morpholino anti… CONTINUE READING

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