A default mode of brain function: A brief history of an evolving idea

@article{Raichle2007ADM,
  title={A default mode of brain function: A brief history of an evolving idea},
  author={Marcus E. Raichle and Abraham Z. Snyder},
  journal={NeuroImage},
  year={2007},
  volume={37},
  pages={1083-1090}
}
The concept of a default mode of brain function arose out of a focused need to explain the appearance of activity decreases in functional neuroimaging data when the control state was passive visual fixation or eyes closed resting. The problem was particularly compelling because these activity decreases were remarkably consistent across a wide variety of task conditions. Using PET, we determined that these activity decreases did not arise from activations in the resting state. Hence, their… 
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Investigating resting brain oscillation and the default mode network based on a source space in various frequency bands using magnetoencephalography found that both resting and DMN activities were augmented in the posterior cingulate in schizophrenia patients.
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This work shows the existence of specific “transmodal” regions containing echoes of multiple Intrinsic connectivity networks, and suggests that these transmodal regions have a particular local spatial organization containing topographic maps that relate to multiple ICNs.
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