A deep convolutional neural network approach to single-particle recognition in cryo-electron microscopy

@article{Zhu2016ADC,
  title={A deep convolutional neural network approach to single-particle recognition in cryo-electron microscopy},
  author={Yanan Zhu and Qi Ouyang and Youdong Mao},
  journal={BMC Bioinformatics},
  year={2016},
  volume={18}
}
BackgroundSingle-particle cryo-electron microscopy (cryo-EM) has become a mainstream tool for the structural determination of biological macromolecular complexes. However, high-resolution cryo-EM reconstruction often requires hundreds of thousands of single-particle images. Particle extraction from experimental micrographs thus can be laborious and presents a major practical bottleneck in cryo-EM structural determination. Existing computational methods for particle picking often use low… 

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