A decreasing rate of neural tube defects following the recommendations for periconceptional folic acid supplementation

@article{Klusmann2005ADR,
  title={A decreasing rate of neural tube defects following the recommendations for periconceptional folic acid supplementation},
  author={Anne Klusmann and Beate Heinrich and Heike St{\"o}pler and Jutta G{\"a}rtner and Ertan Mayatepek and R{\"u}diger von Kries},
  journal={Acta P{\ae}diatrica},
  year={2005},
  volume={94}
}
Background/aim: Neural tube defects (NTDs) are the most common birth defects, resulting in severe mortality and morbidity. In 1995, the supplementation of folic acid periconceptionally was officially recommended in Germany. The impact of the recommendations on the rate of NTDs was assessed. 

Folic Acid and Other Potential Measures in the Prevention of Neural Tube Defects

  • H. Heseker
  • Medicine
    Annals of Nutrition and Metabolism
  • 2011
TLDR
It is shown that not all cases of NTD can be prevented by increasing the folate intake, and the magnitude of the decline depends on the initial NTD rate.

Not all cases of neural-tube defect can be prevented by increasing the intake of folic acid

TLDR
It is shown that not all cases of NTD are preventable by increasing the folate intake, and countries with NTD prevalence close to the observed floor may have much smaller reductions in NTD rates with folic acid fortification.

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TLDR
Recommendations alone remain an ineffective approach in translating the known protective effect of folic acid in population-wide decline in NTD rates, but fortification appears to be effective in reducing NTDs.

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TLDR
Age, higher education level and stability/sufficiency of income appeared to be significant predictors of awareness among Lebanese women and actual folic acid intake was significantly associated with younger age, higher number of pregnancies, planning the last pregnancy and having had that last one after 1990.

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TLDR
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Final results from 18 years of the International Lamotrigine Pregnancy Registry

TLDR
With over 1,500 first-trimester monotherapy exposures, the Registry was powered to detect major teratogenicity and failed to observe an increased MCM frequency with increasing lamotrigine dose.

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TLDR
Women who planned to become pregnant had very low plasma folate in the population, and high NTD risk would remain if women would get pregnant without having taken folic acid supplements.

Plasma folate levels in early to mid pregnancy after a nation-wide folic acid supplementation program in areas with high and low prevalence of neural tube defects in China.

  • Jufen LiuLili Gao A. Ren
  • Medicine
    Birth defects research. Part A, Clinical and molecular teratology
  • 2015
TLDR
Plasma folate levels among pregnant Chinese women increased dramatically after the nation-wide folic acid supplementation program in both rural and urban areas, and in populations of high and low NTD prevalence.

I DENTIFICATION OF M OST C OMMON C ONGENITAL A BNORMALITY T YPES AMONG N EWBORN I NFANTS : A H OSPITAL -B ASED S TUDY

TLDR
It can be concluded that most of the affected newborns were full term, with a slight male predominance, and the incidence of neurological abnormalities was higher than other types of birth defects.

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ZusammenfassungHintergrund. Im Juli 1992 wurde die ESPED-Erhebungseinheit gegründet. In vorliegender Studie wurde untersucht, wie gut Compliance und wissenschaftlicher Impact sind und ob sich mit