A decreasing rate of neural tube defects following the recommendations for periconceptional folic acid supplementation

@article{Klusmann2005ADR,
  title={A decreasing rate of neural tube defects following the recommendations for periconceptional folic acid supplementation},
  author={A. Klusmann and B. Heinrich and Heike St{\"o}pler and J. G{\"a}rtner and E. Mayatepek and R. Kries},
  journal={Acta P{\ae}diatrica},
  year={2005},
  volume={94}
}
Background/aim: Neural tube defects (NTDs) are the most common birth defects, resulting in severe mortality and morbidity. In 1995, the supplementation of folic acid periconceptionally was officially recommended in Germany. The impact of the recommendations on the rate of NTDs was assessed. 
Folic Acid and Other Potential Measures in the Prevention of Neural Tube Defects
  • H. Heseker
  • Medicine
  • Annals of Nutrition and Metabolism
  • 2011
TLDR
It is shown that not all cases of NTD can be prevented by increasing the folate intake, and the magnitude of the decline depends on the initial NTD rate. Expand
Not all cases of neural-tube defect can be prevented by increasing the intake of folic acid
TLDR
It is shown that not all cases of NTD are preventable by increasing the folate intake, and countries with NTD prevalence close to the observed floor may have much smaller reductions in NTD rates with folic acid fortification. Expand
Epidemiology of neural tube defects
TLDR
Despite the implementation of fortification of flour with folic acid since 2001, the prevalence of NTDs in the Kingdom of Saudi Arabia is still high, due to the impact of genetic, syndromic, and chromosomal causes of N TD not preventable by folic Acid. Expand
Trends of selected malformations in relation to folic acid recommendations and fortification: an international assessment.
TLDR
Recommendations alone remain an ineffective approach in translating the known protective effect of folic acid in population-wide decline in NTD rates, but fortification appears to be effective in reducing NTDs. Expand
Awareness and Intake of Folic Acid for the Prevention of Neural Tube Defects Among Lebanese Women of Childbearing Age
TLDR
Age, higher education level and stability/sufficiency of income appeared to be significant predictors of awareness among Lebanese women and actual folic acid intake was significantly associated with younger age, higher number of pregnancies, planning the last pregnancy and having had that last one after 1990. Expand
Describing the Prevalence of Neural Tube Defects Worldwide: A Systematic Literature Review
TLDR
A systematic review and search for NTD prevalence estimates and abstracted data from peer-reviewed literature, birth defects surveillance registries, and reports published between January 1990 and July 2014 highlighted the need for greater NTD surveillance efforts, especially in lower-income countries. Expand
Final results from 18 years of the International Lamotrigine Pregnancy Registry
TLDR
With over 1,500 first-trimester monotherapy exposures, the Registry was powered to detect major teratogenicity and failed to observe an increased MCM frequency with increasing lamotrigine dose. Expand
Plasma folate levels and associated factors in women planning to become pregnant in a population with high prevalence of neural tube defects.
TLDR
Women who planned to become pregnant had very low plasma folate in the population, and high NTD risk would remain if women would get pregnant without having taken folic acid supplements. Expand
Plasma folate levels in early to mid pregnancy after a nation-wide folic acid supplementation program in areas with high and low prevalence of neural tube defects in China.
  • Jufen Liu, Lili Gao, +7 authors A. Ren
  • Medicine
  • Birth defects research. Part A, Clinical and molecular teratology
  • 2015
TLDR
Plasma folate levels among pregnant Chinese women increased dramatically after the nation-wide folic acid supplementation program in both rural and urban areas, and in populations of high and low NTD prevalence. Expand
Outcome of Myelomeningocele Repair and Early Post-operative Complications
TLDR
The study concluded that early diagnosis and prompt management is key to recovery of child with meningomyelocele and early operation without subsequent complications is the backbone of treatment. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 26 REFERENCES
Correction: Prevention of Neural-Tube Defects with Folic Acid in China.
TLDR
Evaluated the outcomes of pregnancy in women who were asked to take a pill containing 400 μg of folic acid alone daily from the time of their premarital examination until the end of their first trimester of pregnancy, and identified 102 and 173 women with neural-tube defects. Expand
International retrospective cohort study of neural tube defects in relation to folic acid recommendations: are the recommendations working?
TLDR
Recommendations alone did not seem to influence trends in neural tube defects up to six years after the confirmation of the effectiveness of folic acid in clinical trials, and a reasonable strategy would be to quickly integrate food fortification with fuller implementation of recommendations on supplements. Expand
Association of neural tube defects and folic acid food fortification in Canada
TLDR
At a population level, folic acid food fortification is associated with a pronounced reduction in open neural tube defects and among 336 963 women who underwent maternal serum screening over 77 months, the prevalence of open Neural tube defects declined. Expand
Diagnosis and prevention of neural tube defects
TLDR
Food fortification is the most practical way of ensuring sufficient folate supplementation and is warranted during the periconceptional period of neural tube defects, and therefore improved medical counseling and parents' decision making. Expand
Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects.
TLDR
A 19% reduction in NTD birth prevalence occurred following folic acid fortification of the US food supply, however, factors other than fortification may have contributed to this decline. Expand
Prevalence of neural tube defects in 20 regions of Europe and the impact of prenatal diagnosis, 1980-1986. EUROCAT Working Group.
  • H. Dolk
  • Medicine
  • Journal of epidemiology and community health
  • 1991
TLDR
There is considerable regional variation in the impact of prenatal diagnosis in terms of frequency and timing of diagnosis and pregnancy termination linked to different policies and practices of prenatal screening. Expand
Dietary folate as a risk factor for neural‐tube defects: evidence from a case‐control study in Western Australia
TLDR
The hypothesis that the dietary intake of folate in early pregnancy protects against the occurrence of isolated neural‐tube defects in infants is supported, and trends were seen when total folate intake was the exposure variable. Expand
Involvement of deprivation and environmental lead in neural tube defects: a matched case-control study
TLDR
There is evidence to suggest that lead is one cause of neural tube defects, especially anencephaly, which could link the known preventive actions of hard water and folic acid. Expand
Prävention von Neuralrohrdefekten durch Folsäurezufuhr in der Frühschwangerschaft. Gemeinsame Empfehlungen der Deutschen Gesellschaft fur Ernährung, Gynäkologie und Geburtshilfe, Humangenetik, Kinderheilkunde. Gesellschaft für Neuropädiatrie
TLDR
Die verfugbaren Daten lassen annehmen, dass die Rate der Neuralrohrdefekte durch die perikonzeptionelle Folsaure reduziert werden kann. Expand
...
1
2
3
...