A decrease of free radical production near critical targets as a cause of maximum longevity in animals.

@article{Barja1994ADO,
  title={A decrease of free radical production near critical targets as a cause of maximum longevity in animals.},
  author={Gustavo Barja and Susana Cadenas and Carlos Eduardo Braidos Rojas and M{\'o}nica L{\'o}pez-Torres and R. P{\'e}rez-Campo},
  journal={Comparative biochemistry and physiology. Biochemistry and molecular biology},
  year={1994},
  volume={108 4},
  pages={501-12}
}
A comprehensive study was performed on the brains of various vertebrate species showing different life energy potentials in order to find out if free radicals are important determinants of species-specific maximum life span. Brain superoxide dismutase, catalase, Se-dependent and independent GSH-peroxidases, GSH-reductase, and ascorbic acid showed significant inverse correlations with maximum longevity, whereas GSH, uric acid, GSSG/GSH, in vitro peroxidation (thiobarbituric acid test), and… CONTINUE READING

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