A decade of transcription factor-mediated reprogramming to pluripotency

@article{Takahashi2016ADO,
  title={A decade of transcription factor-mediated reprogramming to pluripotency},
  author={Kazutoshi Takahashi and S. Yamanaka},
  journal={Nature Reviews Molecular Cell Biology},
  year={2016},
  volume={17},
  pages={183-193}
}
The past 10 years have seen great advances in our ability to manipulate cell fate, including the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This process proved to be remarkably simple from a technical perspective, only needing the host cell and a defined cocktail of transcription factors, with four factors — octamer-binding protein 3/4 (OCT3/4), SOX2, Krüppel-like factor 4 (KLF4) and MYC (collectively referred to as OSKM) — initially used. The… Expand
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