A decade of molecular studies of fragile X syndrome.

@article{Odonnell2002ADO,
  title={A decade of molecular studies of fragile X syndrome.},
  author={William T O'donnell and Stephen T Warren},
  journal={Annual review of neuroscience},
  year={2002},
  volume={25},
  pages={315-38}
}
Fragile X syndrome is one of the most common forms of inherited mental retardation. In most cases the disease is caused by the methylation-induced transcriptional silencing of the fragile X mental retardation 1 (FMR1) gene that occurs as a result of the expansion of a CGG repeat in the gene's 5'UTR and leads to the loss of protein product fragile X mental retardation protein (FMRP). FMRP is an RNA binding protein that associates with translating polyribosomes as part of a large messenger… CONTINUE READING
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