A deadly spread: cellular mechanisms of α-synuclein transfer

  title={A deadly spread: cellular mechanisms of α-synuclein transfer},
  author={Jennifer A Steiner and Elodie Angot and Patrik Brundin},
  journal={Cell Death and Differentiation},
Classically, Parkinson's disease (PD) is linked to dopamine neuron death in the substantia nigra pars compacta. Intracytoplasmic protein inclusions named Lewy bodies, and corresponding Lewy neurites found in neuronal processes, are also key features of the degenerative process in the substantia nigra. The molecular mechanisms by which substantia nigra dopamine neurons die and whether the Lewy pathology is directly involved in the cell death pathway are open questions. More recently, it has… CONTINUE READING
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