A de novo designed protein protein interface.

  title={A de novo designed protein protein interface.},
  author={Po-Ssu Huang and John J. Love and Stephen L. Mayo},
  journal={Protein science : a publication of the Protein Society},
  volume={16 12},
As an approach to both explore the physical/chemical parameters that drive molecular self-assembly and to generate novel protein oligomers, we have developed a procedure to generate protein dimers from monomeric proteins using computational protein docking and amino acid sequence design. A fast Fourier transform-based docking algorithm was used to generate a model for a dimeric version of the 56-amino-acid beta1 domain of streptococcal protein G. Computational amino acid sequence design of 24… CONTINUE READING

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