A database of [18F]-altanserin binding to 5-HT2A receptors in normal volunteers: normative data and relationship to physiological and demographic variables

  title={A database of [18F]-altanserin binding to 5-HT2A receptors in normal volunteers: normative data and relationship to physiological and demographic variables},
  author={Karen H. Adams and Lars H. Pinborg and Claus Svarer and Steen Gregers Hasselbalch and S{\o}ren Holm and Steven Haugbol and Karine Madsen and Vibe G. Frokjaer and Lars Martiny and Olaf Bjarne Paulson and Gitte Moos Knudsen},

Brain imaging of serotonin 4 receptors in humans with [11C]SB207145-PET

A PET [18F]altanserin study of 5-HT2A receptor binding in the human brain and responses to painful heat stimulation

Longitudinal assessment of cerebral 5-HT2A receptors in healthy elderly volunteers: an [18F]-altanserin PET study

In healthy elderly individuals, brain 5-HT2A receptor binding remains stable over 2 years, and acceptable reproducibility and reliability in larger regions and high intra- and interobserver stability allow the use of [18F]-altanserin in longitudinal studies of patients with neuropsychiatric disorders.

The serotonin-1A receptor distribution in healthy men and women measured by PET and [carbonyl-11C]WAY-100635

To explain the higher prevalence of affective disorders in women, further studies are needed to evaluate the relationship between hormonal status and the 5-HT1A receptor expression.

Parametric and Regional Maps of Free Serotonin 5HT1A Receptor Sites in Human Brain as Function of Age in Healthy Humans

The results demonstrate that the number of available 5HT1A-binding sites declines with age, and the correlation between pB and age applied to regions-of-interest revealed significant decline of pB at the rate of 3 or 4% per decade.

Characterization of the serotonin 2A receptor selective PET tracer (R)-[18F]MH.MZ in the human brain

The serotonin receptor subtype 2A antagonist (R)-[18F]MH.MZ has the potential to become the antagonist radiotracer of choice to investigate the human 5-HT2AR system in humans.

The 5-HT2A receptor binding pattern in the human brain is strongly genetically determined

Reproducibility of 5-HT2A receptor measurements and sample size estimations with [18F]altanserin PET using a bolus/infusion approach

This study demonstrates that [18F]altanserin PET with a bolus/infusion design has very low variability, particularly in larger brain regions with high 5-HT2A receptor density, and partial volume correction considerably reduces the sample size required to detect regional changes between groups.



Greater loss of 5-HT(2A) receptors in midlife than in late life.

5-HT(2A) receptor binding decreases dramatically in a variety of brain regions up through midlife, and there was less decrease in late life than in young healthy subjects.

A Database of [11C]WAY-100635 Binding to 5-HT1A Receptors in Normal Male Volunteers: Normative Data and Relationship to Methodological, Demographic, Physiological, and Behavioral Variables

The binding of [(11)C]WAY-100635 was insensitive to changes in brain 5-HT induced by tryptophan infusion and depletion and there were no significant correlations of regional and global BP with common radiochemical, demographic, physiological, and personality variables.

Quantification of 5-HT2A Receptors in the Human Brain Using [18F]Altanserin-PET and the Bolus/Infusion Approach

  • L. PinborgKaren H. Adams G. Knudsen
  • Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2003
It is concluded that 5-HT2A receptor studies can be conducted within 2 h of [18F]altanserin infusion, yielding reliable results.

Test–retest variability of serotonin 5‐HT2A receptor binding measured with positron emission tomography and [18F]altanserin in the human brain

Results demonstrate that the test–retest variability of [18F]altanserin‐specific binding is comparable to that of other PET radiotracers and that the regional specific binding of [ 18F]ALTanser in human brain was correlated with the known regional distribution of 5‐HT2A receptors.

PET quantification of 5-HT2A receptors in the human brain: a constant infusion paradigm with [18F]altanserin.

The results demonstrate the feasibility of equilibrium imaging with [18F]altanserin over more than 5 radioactive half-lives and suggest a method to overcome difficulties associated with lipophilic radiolabeled metabolites.