A d-Amino Acid at the N-Terminus of a Protein Abrogates Its Degradation by the N-End Rule Pathway

@inproceedings{Rabideau2015ADA,
  title={A d-Amino Acid at the N-Terminus
of a Protein Abrogates Its Degradation by the N-End Rule Pathway},
  author={Amy Ellen Rabideau and Bradley L Pentelute},
  booktitle={ACS central science},
  year={2015}
}
Eukaryotes have evolved the ubiquitin (Ub)/proteasome system to degrade polypeptides. The Ub/proteasome system is one way that cells regulate cytosolic protein and amino acids levels through the recognition and ubiquitination of a protein's N-terminus via E1, E2, and E3 enzymes. The process by which the N-terminus stimulates intracellular protein degradation is referred to as the N-end rule. Characterization of the N-end rule has been limited to only the natural l-amino acids. Using a cytosolic… CONTINUE READING
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