A cytotoxicity, optical spectroscopy and computational binding analysis of 4-[3-acetyl-5-(acetylamino)-2-methyl-2,3-dihydro-1,3,4-thiadiazole-2-yl]phenyl benzoate in calf thymus DNA.

@article{Karthikeyan2018ACO,
  title={A cytotoxicity, optical spectroscopy and computational binding analysis of 4-[3-acetyl-5-(acetylamino)-2-methyl-2,3-dihydro-1,3,4-thiadiazole-2-yl]phenyl benzoate in calf thymus DNA.},
  author={Subramani Karthikeyan and Ganesan Bharanidharan and Rajendiran Mangaiyarkarasi and Shanmugavel Chinnathambi and Ragavan Sriram and Krishnaswamy Gunasekaran and Kandasamy Saravanan and Mani Gopikrishnan and Prakasarao Aruna and Singaravelu Ganesan},
  journal={Luminescence : the journal of biological and chemical luminescence},
  year={2018},
  volume={33 4},
  pages={731-741}
}
In this study the interaction mechanism between newly synthesized 4-(3-acetyl-5-(acetylamino)-2-methyl-2, 3-dihydro-1,3,4-thiadiazole-2-yl) phenyl benzoate (thiadiazole derivative) anticancer active drug with calf thymus DNA was investigated by using various optical spectroscopy techniques along with computational technique. The absorption spectrum shows a… CONTINUE READING