A cytotoxic ribonuclease variant with a discontinuous nuclear localization signal constituted by basic residues scattered over three areas of the molecule.

@article{Rodriguez2006ACR,
  title={A cytotoxic ribonuclease variant with a discontinuous nuclear localization signal constituted by basic residues scattered over three areas of the molecule.},
  author={Montserrat Carmona Rodriguez and Antoni Benito and Pere Tubert and Joaquin Leandro Santiesteban Castro and Marc Ribo and Bruno D. Beaumelle and Maria Vilanova},
  journal={Journal of molecular biology},
  year={2006},
  volume={360 3},
  pages={
          548-57
        }
}
Nuclear import of proteins is determined by specific signals that allow them to bind to receptors that mediate their energy-dependent transport through the nuclear pore. These signals are termed nuclear localization signals and do not constitute a specific consensus sequence. Among them, the most characterized correspond to monopartite and bipartite nuclear localization signals, which interact with the importin alpha/beta heterodimer. We previously described a cytotoxic variant of human… CONTINUE READING
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