A cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism is associated with autoimmune Addison's disease in English patients.

@article{Kemp1998ACT,
  title={A cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism is associated with autoimmune Addison's disease in English patients.},
  author={E Helen Kemp and Ramzi A. Ajjan and Eystein Sverre Husebye and Pamela M Peterson and Raivo Uibo and Helen Imrie and Simon H. S. Pearce and Philip F. Watson and Anthony P. Weetman},
  journal={Clinical endocrinology},
  year={1998},
  volume={49 5},
  pages={609-13}
}
OBJECTIVE Recent studies have demonstrated an association between a microsatellite polymorphism of the CTLA-4 gene, specifically a 106 base pair allele, and both Graves' disease and autoimmune hypothyroidism. The aim of the present study was to determine whether the same polymorphism of the CTLA-4 gene was associated with autoimmune Addison's disease. DESIGN AND PATIENTS We analysed a microsatellite polymorphism (variant lengths of a dinucleotide (AT)n repeat) within exon 3 of the CTLA-4 gene… CONTINUE READING
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