A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

@article{Siekierka1989ACB,
  title={A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin},
  author={John J. Siekierka and S. H. Y. Hung and Martin Poe and C S Lin and Nolan H. Sigal},
  journal={Nature},
  year={1989},
  volume={341},
  pages={755-757}
}
CYCLOSPORIN A and the newly discovered immunosuppressant, FK-506, are potent inhibitors of T cell activation1. In addition to their clinical importance in the prevention of allograft rejection, cyclosporin A and FK-506 represent important reagents for the study of the molecular mechanisms of lymphocyte activation. Cyclosporin A, a cyclic undecapeptide and FK-506, a macrolide, although chemically distinct, inhibit similar lymphocyte activation responses1, 2. The earliest responses inhibited in… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
180 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 180 extracted citations

Similar Papers

Loading similar papers…