A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation

@article{Cant2017ACR,
  title={A cytoplasmic role of Wnt/$\beta$-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation},
  author={Claudio Cant{\'u} and Pierfrancesco Pagella and Tania D. Shajiei and Dario Zimmerli and Tomas Valenta and George Hausmann and Konrad Basler and Thimios A. Mitsiadis},
  journal={Science Signaling},
  year={2017},
  volume={10}
}
Transcriptional cofactors that participate in Wnt/β-catenin signaling act in the cytoplasm to promote proper development of tooth enamel. Cytoplasmic functions for transcriptional cofactors in teeth Bcl9, Bcl9l, and Pygo2 interact with transcription factors, such as the Wnt-regulated protein β-catenin, to regulate gene expression. Cantù et al. reveal that these proteins also have cytoplasmic functions during tooth development and are particularly important for the formation of enamel. Mice… 
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