A cytoplasmic region determines single-channel conductance in 5-HT3 receptors

@article{Kelley2003ACR,
  title={A cytoplasmic region determines single-channel conductance in 5-HT3 receptors},
  author={Stephen P. Kelley and James I. Dunlop and Ewen F. Kirkness and J J Lambert and J Andrew Peters},
  journal={Nature},
  year={2003},
  volume={424},
  pages={321-324}
}
5-Hydroxytryptamine type 3 (5-HT3) receptors are cation-selective transmitter-gated ion channels of the Cys-loop superfamily. The single-channel conductance of human recombinant 5-HT3 receptors assembled as homomers of 5-HT3A subunits, or heteromers of 5-HT3A and 5-HT3B subunits, are markedly different, being 0.4 pS (refs 6, 9) and 16 pS (ref. 7), respectively. Paradoxically, the channel-lining M2 domain of the 5-HT3A subunit would be predicted to promote cation conduction, whereas that of the… CONTINUE READING
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