A cytoplasmic inhibitor of the JNK signal transduction pathway.

@article{Dickens1997ACI,
  title={A cytoplasmic inhibitor of the JNK signal transduction pathway.},
  author={Mark Dickens and J. Scott Rogers and Jonathan Cavanagh and Arthur Raitano and Zhenbiao Xia and J R Halpern and Michael E. Greenberg and Charles L Sawyers and Roger J Davis},
  journal={Science},
  year={1997},
  volume={277 5326},
  pages={693-6}
}
The c-Jun amino-terminal kinase (JNK) is a member of the stress-activated group of mitogen-activated protein (MAP) kinases that are implicated in the control of cell growth. A murine cytoplasmic protein that binds specifically to JNK [the JNK interacting protein-1 (JIP-1)] was characterized and cloned. JIP-1 caused cytoplasmic retention of JNK and inhibition of JNK-regulated gene expression. In addition, JIP-1 suppressed the effects of the JNK signaling pathway on cellular proliferation… CONTINUE READING
Highly Influential
This paper has highly influenced 22 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 250 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Proc

  • A. B. Raitano, J. R. Halpern, T. M. Hambuch, C. L. Sawyers
  • Natl. Acad. Sci. U.S.A. 92,
  • 1174
Highly Influential
7 Excerpts

Genes Dev

  • I. M. Verma, J. K. Stevenson, E. M. Schwarz, D. Van Antwerp, S. Miyamoto
  • 9, 2723 (1995); R. B. McNeill and R. J. Colbran…
  • 1004

Similar Papers

Loading similar papers…