A cytoplasmic inhibitor of the JNK signal transduction pathway.

  title={A cytoplasmic inhibitor of the JNK signal transduction pathway.},
  author={Mark Dickens and J. Scott Rogers and Jonathan Cavanagh and Arthur Raitano and Zhenbiao Xia and J R Halpern and Michael E. Greenberg and Charles L Sawyers and Roger J Davis},
  volume={277 5326},
The c-Jun amino-terminal kinase (JNK) is a member of the stress-activated group of mitogen-activated protein (MAP) kinases that are implicated in the control of cell growth. A murine cytoplasmic protein that binds specifically to JNK [the JNK interacting protein-1 (JIP-1)] was characterized and cloned. JIP-1 caused cytoplasmic retention of JNK and inhibition of JNK-regulated gene expression. In addition, JIP-1 suppressed the effects of the JNK signaling pathway on cellular proliferation… CONTINUE READING
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