A cytomegalovirus inhibitor of gamma interferon signaling controls immunoproteasome induction.

@article{Khan2004ACI,
  title={A cytomegalovirus inhibitor of gamma interferon signaling controls immunoproteasome induction.},
  author={Selina Khan and Albert Zimmermann and Michael Basler and Marcus Groettrup and Hartmut Hengel},
  journal={Journal of virology},
  year={2004},
  volume={78 4},
  pages={
          1831-42
        }
}
Both human and mouse cytomegaloviruses (HCMV and MCMV) avoid peptide presentation through the major histocompatibility complex (MHC) class I pathway to CD8(+) T cells. Within the MHC class I pathway, the vast majority of antigenic peptides are generated by the proteasome system, a multicatalytic protease complex consisting of constitutive subunits, three of which can be replaced by enzymatically active gamma interferon (IFN-gamma)-inducible subunits, i.e., LMP2, LMP7, and MECL1, to form the so… CONTINUE READING

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