A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

@article{DiDonato1997ACI,
  title={A cytokine-responsive I$\kappa$B kinase that activates the transcription factor NF-$\kappa$B},
  author={Joseph A. DiDonato and Makio Hayakawa and David M. Rothwarf and Ebrahim Zandi and Michael Karin},
  journal={Nature},
  year={1997},
  volume={388},
  pages={548-554}
}
Nuclear transcription factors of the NF-κB/Rel family are inhibited by IκB proteins, which inactivate NF-κB by trapping it in the cell cytoplasm. Phosphorylation of IκBs marks them out for destruction, thereby relieving their inhibitory effect on NF-κB. A cytokine-activated protein kinase complex, IKK (for IκB kinase), has now been purified that phosphorylates IκBs on the sites that trigger their degradation. A component of IKK was molecularly cloned and identified as a serine kinase. IKK turns… 
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