A cytokine-mediated link between innate immunity, inflammation, and cancer.

  title={A cytokine-mediated link between innate immunity, inflammation, and cancer.},
  author={Wan-Wan Lin and Michael Karin},
  journal={The Journal of clinical investigation},
  volume={117 5},
It has been established that cancer can be promoted and/or exacerbated by inflammation and infections. Indeed, chronic inflammation orchestrates a tumor-supporting microenvironment that is an indispensable participant in the neoplastic process. The mechanisms that link infection, innate immunity, inflammation, and cancer are being unraveled at a fast pace. Important components in this linkage are the cytokines produced by activated innate immune cells that stimulate tumor growth and progression… CONTINUE READING
Highly Influential
This paper has highly influenced 35 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.
672 Citations
125 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 672 extracted citations


Publications referenced by this paper.
Showing 1-10 of 125 references

TGFβ suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling

  • C Becker
  • 2004
Highly Influential
10 Excerpts

Similar Papers

Loading similar papers…