A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis

  title={A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis},
  author={Koen Vandenbroeck and J Alvarez and Bhairavi Swaminathan and Iraide Alloza and Fuencisla Matesanz and Elena Urcelay and Manuel Comabella and Antonio Alcina and Mar{\'i}a Fedetz and Miguel Angel Garc{\'i}a Ortiz and Guillermo Izquierdo and Oscar Fern{\'a}ndez and Naiara Rodr{\'i}guez-Ezpeleta and Carlos Matute and Stacy J. Caillier and R. X. Arroyo and Xavier Montalban and Jorge Oksenberg and Alfredo Rodr{\'i}guez Antig{\"u}edad and A M Aransay},
  journal={Genes and Immunity},
Cytokine and cytokine receptor genes, including IL2RA, IL7R and IL12A, are known risk factors for multiple sclerosis (MS). Excitotoxic oligodendroglial death mediated by glutamate receptors contributes to demyelinating reactions. In the present study, we screened 368 single-nucleotide polymorphisms (SNPs) in 55 genes or gene clusters coding for cytokines, cytokine receptors, suppressors of cytokine signaling (SOCS), complement factors and glutamate receptors for association with MS in a Spanish… CONTINUE READING
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Differential expression of SOCS 1 in macrophages in relapsing - remitting and chronic EAE and its role in disease severity

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