A cytokine-centric view of the pathogenesis and treatment of autoimmune arthritis.

@article{Astry2011ACV,
  title={A cytokine-centric view of the pathogenesis and treatment of autoimmune arthritis.},
  author={Brian Astry and Erin Harberts and Kamal D. Moudgil},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={2011},
  volume={31 12},
  pages={
          927-40
        }
}
Cytokines are immune mediators that play an important role in the pathogenesis of rheumatoid arthritis (RA), an autoimmune disease that targets the synovial joints. The cytokine environment in the peripheral lymphoid tissues and the target organ (the joint) has a strong influence on the outcome of the initial events that trigger autoimmune inflammation. In susceptible individuals, these events drive inflammation and tissue damage in the joints. However, in resistant individuals, the… CONTINUE READING

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