A cytogenetic study of 397 consecutive acute myeloid leukemia cases identified three with a t(7;21) associated with 5q abnormalities and exhibiting similar clinical and biological features, suggesting a new, rare acute myeloid leukemia entity.

@article{Jeandidier2012ACS,
  title={A cytogenetic study of 397 consecutive acute myeloid leukemia cases identified three with a t(7;21) associated with 5q abnormalities and exhibiting similar clinical and biological features, suggesting a new, rare acute myeloid leukemia entity.},
  author={Eric Jeandidier and Carine Gervais and Isabelle Radford-weiss and Estelle Zink and Catherine Gangneux and Alice Eischen and Anne C{\'e}cile Galoisy and Catherine H{\'e}lias and Laurent Dano and Ornella Cammarata and Georges Jung and In{\`e}s Harzallah and Eric Gu{\'e}rin and Lionel Martzolff and Bernard Dr{\'e}nou and Bruno Lioure and C{\'e}line Tancr{\'e}di and Val{\'e}rie Rimelen and Laurent Mauvieux},
  journal={Cancer genetics},
  year={2012},
  volume={205 7-8},
  pages={365-72}
}
The RUNX1 gene is implicated in numerous chromosomal translocations that occur in acute myeloid leukemia (AML) and result in chimeric genes. In this study, 397 consecutive AML cases were analyzed using RUNX1 fluorescence in situ hybridization (FISH) probes. Three cases of the recently described translocation, t(7;21)(p22;q22), were identified, which expressed RUNX1-USP42 (ubiquitin-specific protease 42) fusion transcripts, associated with 5q abnormalities and hyperploidy. These cases displayed… CONTINUE READING