A cytochrome c mutant with high electron transfer and antioxidant activities but devoid of apoptogenic effect.

Abstract

A cytochrome c mutant lacking apoptogenic function but competent in electron transfer and antioxidant activities has been constructed. To this end, mutant species of horse and yeast cytochromes c with substitutions in the N-terminal alpha-helix or position 72 were obtained. It was found that yeast cytochrome c was much less effective than the horse protein… (More)

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