A cytochrome P450 monooxygenase gene required for biosynthesis of the trichothecene toxin harzianum A in Trichoderma

@article{Cardoza2019ACP,
  title={A cytochrome P450 monooxygenase gene required for biosynthesis of the trichothecene toxin harzianum A in Trichoderma},
  author={R. Cardoza and S. McCormick and L. Lindo and Hye-Seon Kim and E. R. Olivera and D. Nelson and R. Proctor and S. Guti{\'e}rrez},
  journal={Applied Microbiology and Biotechnology},
  year={2019},
  volume={103},
  pages={8087 - 8103}
}
Trichothecenes are sesquiterpene toxins produced by diverse fungi, including some species of Trichoderma that are potential plant disease biocontrol agents. Trichoderma arundinaceum produces the trichothecene harzianum A (HA), which consists of the core trichothecene structure (12,13-epoxytrichothec-9-ene, EPT) with a linear polyketide-derived substituent (octa-2,4,6-trienedioyl) esterified to an oxygen at carbon atom 4. The genes required for biosynthesis of EPT and the eight-carbon polyketide… Expand
3 Citations
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