A cytochrome P450 monooxygenase gene required for biosynthesis of the trichothecene toxin harzianum A in Trichoderma

  title={A cytochrome P450 monooxygenase gene required for biosynthesis of the trichothecene toxin harzianum A in Trichoderma},
  author={R. Cardoza and S. McCormick and L. Lindo and Hye-Seon Kim and E. R. Olivera and D. Nelson and R. Proctor and S. Guti{\'e}rrez},
  journal={Applied Microbiology and Biotechnology},
  pages={8087 - 8103}
Trichothecenes are sesquiterpene toxins produced by diverse fungi, including some species of Trichoderma that are potential plant disease biocontrol agents. Trichoderma arundinaceum produces the trichothecene harzianum A (HA), which consists of the core trichothecene structure (12,13-epoxytrichothec-9-ene, EPT) with a linear polyketide-derived substituent (octa-2,4,6-trienedioyl) esterified to an oxygen at carbon atom 4. The genes required for biosynthesis of EPT and the eight-carbon polyketide… Expand
3 Citations
Genetic bases for variation in structure and biological activity of trichothecene toxins produced by diverse fungi
Fungal P450 monooxygenases - the diversity in catalysis and their promising roles in biocontrol activity
Herbicidal efficacy of harzianums produced by the biofertilizer fungus, Trichoderma brevicompactum


Relevance of trichothecenes in fungal physiology: disruption of tri5 in Trichoderma arundinaceum.
Effects of Trichothecene Production on the Plant Defense Response and Fungal Physiology: Overexpression of the Trichoderma arundinaceum tri4 Gene in T. harzianum
TRI12, a trichothecene efflux pump from Fusarium sporotrichioides: gene isolation and expression in yeast
Role of Trichoderma arundinaceum tri10 in regulation of terpene biosynthetic genes and in control of metabolic flux.
Effect of deletion of a trichothecene toxin regulatory gene on the secondary metabolism transcriptome of the saprotrophic fungus Trichoderma arundinaceum.
Identification of Loci and Functional Characterization of Trichothecene Biosynthesis Genes in Filamentous Fungi of the Genus Trichoderma †
Evolution of structural diversity of trichothecenes, a family of toxins produced by plant pathogenic and entomopathogenic fungi
Genome-wide analysis of cytochrome P450s of Trichoderma spp.: annotation and evolutionary relationships