A cyclophilin functions in pre-mRNA splicing.

  title={A cyclophilin functions in pre-mRNA splicing.},
  author={David S. Horowitz and Edward J. Lee and Stephen A. Mabon and Tom Misteli},
  journal={The EMBO journal},
  volume={21 3},
We report that the cyclophilin USA-CyP is part of distinct complexes with two spliceosomal proteins and is involved in both steps of pre-mRNA splicing. The splicing factors hPrp18 and hPrp4 have a short region of homology that defines a high affinity binding site for USA-CyP in each protein. USA-CyP forms separate, stable complexes with hPrp18 and hPrp4 in which the active site of the cyclophilin is exposed. The cyclophilin inhibitor cyclosporin A slows pre-mRNA splicing in vitro, and we show… CONTINUE READING

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