A cyclooxygenase-2 inhibitor ameliorates behavioral impairments induced by striatal administration of epidermal growth factor.

@article{Mizuno2007ACI,
  title={A cyclooxygenase-2 inhibitor ameliorates behavioral impairments induced by striatal administration of epidermal growth factor.},
  author={Makoto Mizuno and Hidekazu Sotoyama and Eri Narita and Hiroki Kawamura and Hisaaki Namba and Yingjun Zheng and Takeyoshi Eda and Hiroyuki Nawa},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 38},
  pages={10116-27}
}
Consistent with the hypothesis that neuroinflammatory processes contribute to the neuropathology of schizophrenia, the protein levels of epidermal growth factor (EGF) and its receptor ErbB1 are abnormal in patients with schizophrenia. To evaluate neuropathological significance of this abnormality, we established an animal model for behavioral deficits by administering EGF into the striatum and evaluated the effects of cyclooxygenase-2 (Cox-2) inhibitor celecoxib. Intracranial infusion of EGF… CONTINUE READING

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EGF receptor (ErbB1) expression of nigral dopamine neurons in human and monkey; impact on Parkinsonism

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