A cyclized peptide derived from alpha fetoprotein inhibits the proliferation of ER-positive canine mammary cancer cells.

@article{Torres2009ACP,
  title={A cyclized peptide derived from alpha fetoprotein inhibits the proliferation of ER-positive canine mammary cancer cells.},
  author={Cristian Gabriel Torres and Ana Mar{\'i}a Moure Pino and Walter Daniel Sierralta},
  journal={Oncology reports},
  year={2009},
  volume={21 6},
  pages={
          1397-404
        }
}
The effects of estradiol (E2) and of an AFP-derived cyclized peptide (cP) on the proliferation of primary cultures of cancer cells isolated from spontaneous canine mammary tumors were studied. The cellular response to E2 and cP was related to the expression of estradiol receptor (isoforms alpha and beta). In ER-positive cells, 2 nM estradiol increased cell proliferation and the phosphorylation of ERK1/2; 2 microg/ml cP inhibited all these effects. Estradiol also increased HER2 immunoreactivity… CONTINUE READING

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