A cyclitol derivative as a replication inhibitor from the marine sponge Petrosia sp.

  title={A cyclitol derivative as a replication inhibitor from the marine sponge Petrosia sp.},
  author={D. K. Kim and Y J Lim and J S Kim and J H Park and N. D. Kim and Kwang Sik Im and J Hong and J. H. Jung},
  journal={Journal of natural products},
  volume={62 5},
A bioactive cyclitol derivative (1) was isolated from the marine sponge Petrosia sp. The chemical structure of 1 was determined as (2S)-1-O-(2',3',4',5'-tetrahydroxycyclopentyl)-3-O-(10' '-methylhexadecyl)glycerol. Compound 1 inhibited DNA replication in vitro at the level of initiation. 
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