A cut-point value of uncarboxylated to carboxylated index is associated with glycemic status markers in type 2 diabetes.

@article{VillafnBernal2014ACV,
  title={A cut-point value of uncarboxylated to carboxylated index is associated with glycemic status markers in type 2 diabetes.},
  author={Jos{\'e} Rafael Villaf{\'a}n-Bernal and Mara Ana{\'i}s Llamas-Covarrubias and Jos{\'e} Francisco Mu{\~n}{\'o}z-Valle and Edgar Alfonso Rivera-Le{\'o}n and Mercedes Elvira Gonz{\'a}lez-Hita and Blanca Estela Bastidas-Ram{\'i}rez and Carmen Magdalena Gurrola-D{\'i}az and Juan Armend{\'a}riz-Borunda and Sergio S{\'a}nchez-Enr{\'i}quez},
  journal={Journal of investigative medicine : the official publication of the American Federation for Clinical Research},
  year={2014},
  volume={62 1},
  pages={33-6}
}
BACKGROUND The uncarboxylated osteocalcin (ucOC) has been described as a regulator of glucose metabolism in mice, and it is decreased in human type 2 diabetes mellitus (T2D). Although inversely correlated with serum glucose, insulin, and glycated hemoglobin, it is unclear if ucOC decrement is caused by diabetes or plays a role in the pathogenesis and/or progression of the disease. Whatever the case may be, diabetes affects osteoblast gene expression, and possibly the proportion of ucOC over… CONTINUE READING