A custom microarray platform for analysis of microRNA gene expression

  title={A custom microarray platform for analysis of microRNA gene expression},
  author={John Michael Thomson and Joel Parker and Charles M. Perou and Scott M. Hammond},
  journal={Nature Methods},
MicroRNAs are short, noncoding RNA transcripts that post-transcriptionally regulate gene expression. Several hundred microRNA genes have been identified in Caenorhabditis elegans, Drosophila, plants and mammals. MicroRNAs have been linked to developmental processes in C. elegans, plants and humans and to cell growth and apoptosis in Drosophila. A major impediment in the study of microRNA function is the lack of quantitative expression profiling methods. To close this technological gap, we have… CONTINUE READING
Highly Influential
This paper has highly influenced 19 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 292 extracted citations

Differential expression of oncogenic miRNAs in proliferating and senescent human fibroblasts

Molecular and Cellular Biochemistry • 2011
View 3 Excerpts
Highly Influenced

The expression profile of microRNAs in a model of 7,12-dimethyl-benz[a]anthrance-induced oral carcinogenesis in Syrian hamster

Journal of experimental & clinical cancer research : CR • 2009
View 5 Excerpts
Highly Influenced

microRNAs as oncogenes and tumor suppressors.

View 8 Excerpts
Highly Influenced

A preliminary analysis of microRNA as potential clinical biomarker for schizophrenia.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics • 2015
View 6 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 25 references

An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues.

Proceedings of the National Academy of Sciences of the United States of America • 2004

Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation

Sempere, L.F
Genome Biol. 5, • 2004

The microRNA Registry

Nucleic Acids Research • 2004

genomics, biogenesis, mechanism, and function

Bartel, D. P. MicroRNAs
Cell 116, 281–297 • 2004

Similar Papers

Loading similar papers…