A current view of the epigenome in mouse primordial germ cells.

  title={A current view of the epigenome in mouse primordial germ cells.},
  author={Yasuhisa Matsui and Kentaro Mochizuki},
  journal={Molecular reproduction and development},
  volume={81 2},
Primordial germ cells (PGCs) are undifferentiated germ line cells in embryos that emerge at early stages of embryonic development, and then differentiate into eggs or sperm in gonads to give rise to individuals of successive generations. During germ cell development, several dynamic changes in epigenetic modifications including DNA methylation and histone modifications occur, and these changes are thought to be reprogramming processes that are required for germ cells to confer totipotency to… CONTINUE READING
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