A current understanding of Fc epsilon RI-dependent mast cell activation.

@article{Rivera2008ACU,
  title={A current understanding of Fc epsilon RI-dependent mast cell activation.},
  author={Juan Francisco Rivera and Ana Olivera},
  journal={Current allergy and asthma reports},
  year={2008},
  volume={8 1},
  pages={14-20}
}
Mast cell activation via the high-affinity immunoglobulin (Ig) E receptor Fc epsilon RI is a topic of extensive investigation with therapeutic potential in allergic disease. The protein tyrosine kinases Fyn, Lyn, and Syk are intimately linked with the early events initiated by allergen-mediated aggregation of IgE-occupied Fc epsilon RI. Fyn and Lyn initiate signaling events that are organized by adaptor molecules, which compartmentalize and coordinate the activity of activated protein and lipid… CONTINUE READING

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