A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells

@article{Wada2007ACR,
  title={A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells},
  author={Teiji Wada and Kenji Hata and Kazuhito Yamaguchi and Kazuhiro Shiozaki and Koichi Koseki and Setsuko Moriya and Taeko Miyagi},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={2483-2490}
}
Human plasma membrane-associated sialidase (NEU3), a key enzyme for ganglioside degradation, is markedly upregulated in human cancers, leading to apoptosis suppression. To define molecular mechanisms and the possible target for NEU3, its encoding gene was silenced by small interference RNA (siRNA) or overexpressed in human cells. NEU3 siRNA-induced apoptosis with no special stimuli in HeLa cells, accompanied with decreased Bcl-xL and increased mda7 and GM3 synthase mRNA levels, whereas… CONTINUE READING

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